show episodes
 
The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
 
Biology is breaking out of the lab and clinic—and into our daily lives. Our new ability to engineer biology is transforming not just science, research, and healthcare, but how we produce our food, the materials we use, how we manufacture, and much, much more. From the latest scientific advances to the biggest trends, this show explores all the ways biology is today where the computing revolution was 50 years ago: on the precipice of revolutionizing our world in ways we are only just beginnin ...
 
16 Minutes on the News is a short news podcast where we cover the top headlines of the week, the a16z podcast way -- why are these topics in the news; what's real, what's hype from our vantage point; and what are our experts' quick takes on these trends? About the a16z Podcast: Discusses tech and culture trends, news, and the future -- especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This ...
 
Conversations on Clubhouse and beyond -- to capture and share many of the live discussions and events featuring, hosted, or co-hosted by a16z partners (with outside voices too). Many of these different discussions and events take place on the social audio/ drop-in chat app Clubhouse; to attend those in real time or sign up for the app please visit joinclubhouse.com. As a reminder, all content posted here is provided for informational purposes only, and should not be relied upon as legal, bus ...
 
Most business podcasts follow a similar format: find a successful CEO and have them tell their story. This is not that show. Zero to IPO tackles real world problems with real world experience, featuring actionable advice and anecdotes from some of the world's most innovative founders. In season one, we broke down each stage of a company's growth cycle on a granular level with everyone from Parker Harris of Salesforce.com, to Julia Hartz of Eventbrite and Marc Andreessen of Andreessen Horowit ...
 
Vijay Peduru provides one startup idea every Tuesday. He loves Venture capitalists like Paul Graham(Y-Combinator), Naval Ravikanth (angel.co),Marc Andreessen(Andreessen Horowitz) and other successful VC's.He is an avid reader of their blogs and listener of their podcasts and speeches. He looks deep and deciphers the startups they invest in and became successful(acquired or IPO) and he uncovers several trends . He comes up with Startup ideas with these successful trends and posts them in this ...
 
Sam Altman and the folks from Y Combinator offer up an amazing course in "How To Start A Startup" at Stanford. Course includes lectures from: Sam Altman, Dustin Moskovitz, Paul Graham, Adora Cheung, Peter Thiel, Alex Schultz, Kevin Hale, Marc Andreessen, Ron Conway, Ben Silbermann, Alfred Lin, Patrick and John Collison, Aaron Levie, Reid Hoffman, Keith Rabois, Ben Horowitz, Marissa Mayer, Hosian Rahman, Kirsty Nathoo, Carolynn Levy, and more
 
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show series
 
mRNA research before COVID and how "mRNA is code" [3:21] The early days of COVID: designing a vaccine in 48 hours [5:44] The software behind the vaccine: getting mRNA researchers out of Excel and into a drug design studio [9:11] The first draft of the vaccine was the final draft [11:10] How the government sped up vaccine development for COVID [12:1…
 
Welcome to 16 Minutes, the a16z show where we talk about tech trends in the news, what’s hype and what’s real, and the long arc of innovation. In today's episode we’re talking about the latest developments and trends in cybercrime – including the trends of ransomware, and, attacks on physical infrastructure. First (0:00 - 6:07), we have the recent …
 
When it comes to healthcare, the topic of how expensive it is and what we can do to lower costs is always top of mind. One area with particularly steep costs is the emergency department. These are hospital departments that can take care of pretty much anything from a cut to a car wreck. But going to an emergency department for something as simple a…
 
If there is one rule in biology, it is that there is an exception to every rule. This includes even the basic biochemistry of DNA, which was once thought to be universal. On this episode, host Lauren Richardson and Judy Savitskaya (a16z bio deal team member and synthetic biology expert), discuss the results and implications three related articles c…
 
Fab 5 Freddy on New York in the 70s, Warhol, Blondie, Basquiat, and Yo! MTV Raps [1:40] Contrarian strategy and challenging assumptions [5:12] Boring AI and solving meaningful problems [8:42] Drop-in audio copycats [14:39] How is copying software different from remixing hip hop? [21:07] Do you want a CEO as an inventor or an operator? [24:12] Recru…
 
This episode was recorded in March of 2019 to celebrate the 20th anniversary of Folding at Home, the distributed computing project for simulating protein dynamics, and originally aired on The a16z Podcast. Folding at Home is run on millions of devices, is the world’s largest supercomputer, and tackles some of biology’s toughest problems, including …
 
Given recent buzz and ongoing debates around the Endless Frontiers Act -- which some have described as “the most important piece of legislation no one's heard of” -- this episode is a rerun of an episode from last year, recorded after said act was initially unveiled. The short discussion covers the broader topic and theme of funding science and inn…
 
The six functions in an enterprise marketing org [2:54] Why product marketing is the killer function [6:52] How do you hire a world class product marketer? [11:16] Is community or developer evangelists its own function or part of product marketing? [17:46] How does community tie into the marketing funnel? [22:56] Is community top of funnel, an acce…
 
What did Substack think about the NYTimes article "Why We’re Freaking Out About Substack" [1:01] What is Substack? [4:40] The issues with social media content models and how Substack is different [5:54] What about the echo chamber? [8:54] Turning cultural principles (e.g., freedom of the press) into actual culture [12:00] Will Substack replace trad…
 
eBay to today, a brief history of collectibles and tech [1:03] Are collectibles about sentiment or investment? [5:13] How do you bring the excitement of a collection to digital goods? [13:34] Is the future of all collectibles digital? [20:20] The role of blockchain and NFTs [26:39] Are collectible marketplaces different from other marketplaces? [32…
 
Recently, a16z and the Stanford Center for Blockchain Research hosted the NFT Virtual Summit, which brought together leading thinkers and builders on the topic of NFTs, or non-fungible tokens — these tokens are enabling new creator and ownership economies to emerge. We’ve covered NFTs in other podcasts and articles, including a curated list of read…
 
For videos of the NFT Virtual Summit, visit a16z.com. Session 1: The Future of the Digital Ownership Economy with Dan Boneh (Stanford University) and Chris Dixon (a16z) What is an NFT? [3:01] Why are NFTs so big right now? [7:04] The most exciting programmable ownership structures [11:36] NFTs and composability: what can you do with NFTs? [15:16] H…
 
What inspired Eric and Sam to start Dyno [4:09] How does the use of ML impact Dyno's GTM [10:40] The current challenges of gene therapy [21:43] Why Dyno wants to be a horizontal platform for gene therapy [30:56] How does Dyno think about competition [44:23] After party and audience Q&A [52:01] It's Time to Heal, Mondays at 5pm PT on Clubhouse. Join…
 
On the path from scientific discovery to new drug, the clinical trial is a huge — and critical — hurdle. Clinical trials are themselves experiments, and to make sure that they are doing the best possible job at determining the safety and efficacy of the new drug, we need to be able to do experiments on those experiments. But how do you do that in s…
 
Note: the recording of this episode starts a minute or two into the show. Ali recommends: The Hard Thing about Hard Things by Ben Horowitz [0:18] Ben recommends: High Output Management by Andy Grove [4:36] Marc recommends: Who Really Matters: The Core Group Theory of Power, Privilege, and Success by Art Kleiner [10:48] Best read for enterprise sale…
 
How Ben took over Take Two [1:42] How digital distribution and publishing changed gaming [8:36] What is a next generation publisher? [13:51] Can publishers add value as tastemakers? [17:36] How do you make sure studios ship on time? And in the era of persistent game worlds, does it matter? [22:01] Lessons learned from Take Two [27:27] Taking the lo…
 
Robert's foundational experiences growing up [3:03] His introduction to computers, how he got an internship at Bell Labs, and what he learned there [6:38] Why he studied chemical engineering [13:15] Working at Kraft and engineering macaroni and cheese [15:08] Why he moved to investing [18:12] How he realized that it made sense to do buyouts in ente…
 
What happened at Basecamp and could it have gone differently? [3:51] When did Basecamp turn into a 4B? [7:45] Why were buyouts a good policy for Basecamp and Coinbase? [10:26] Why not have a more moderate policy? [11:56] What makes something "political"? [14:45] What about when political issues have a personal impact on employees? [19:18] What happ…
 
What are red teams and blue teams? [2:03] How Cedric cracked Mac Gatekeeper [6:55] Apple's response [15:22] Cedric's craziest hack [19:24] Red team advice for the blue team [22:02] Audience Q&A [26:31] 🔐Breach of the Week 🔐looks at who got hacked, how it happened, and what it means for the industry. 🎙With hosts Joel de la Garza (a16z Security Opera…
 
They say you should never judge a book by its cover, but can you judge a cell by its shape? On this episode, host Lauren Richardson is joined by Maddison Masaeli (CEO and cofounder of Deepcell), and a16z general partner Vijay Pande (whose lab at Stanford focused on the development of novel computational methods for simulating biology), to discuss w…
 
On this episode of the a16z Bio Clubhouse Show, a16z general partners Vineeta Agarwala, Julie Yoo, Vijay Pande, and Jorge Conde talk to guest Shantanu Nundy, the Chief Medical Officer of Accolade. The conversation covers Dr. Nundy's new book, "Care After Covid: What the Pandemic Revealed Is Broken in Healthcare and How to Reinvent It", the next ste…
 
Why does it feel like there's a database for everything? [4:46] What is the actual use case and market for streaming? [9:34] How real is real time? [20:12] Can you do everything in SQL? [25:08] Is the future SQL extensions or does SQL become embedded in data frames? [40:19] Is database consolidation coming? How many different systems will we have? …
 
What is AI? [2:27] AI is statistics, not consciousness [7:05] Why then so much talk about the singularity? [12:12] AI breakthroughs and FAANGs [17:21] Building the AI toolchain [26:07] AI applications in bio and medicine [30:19] Ali's favorite AI use cases [34:35] What will AI do to jobs? [39:27] AI in 10 years [46:09] Snowflake, Databricks, data L…
 
In this episode: Melody McCloskey - CEO of StyleSeat, a booking platform that connects stylists and beauty professionals with clients. Since its founding in 2011, StyleSeat has powered 150 million beauty appointments and generated over $6.5 billion in revenue for beauty professionals. The company has created a loyal community of the country’s leadi…
 
On this episode of the a16z Bio Clubhouse Show, a16z general partners Julie Yoo and Jorge Conde, managing partner Scott Kupor, and market development partner Venkat Mocherla talk to guest Florian Otto, cofounder and CEO of Cedar. The conversation covers how to improve two of the trickiest aspect of healthcare: price transparency and patient engagem…
 
Neuroscientists have long been trying to determine what happens in the brain during sleep, but to date, they have overlooked a key player: astrocytes. These star-shaped cells were once thought to be the glue that held the brain together, but we are now beginning to appreciate their importance in a variety of brain functions. In this episode, host L…
 
Playing out against the backdrop of a global pandemic (including recent massive surges in regions around the world) is the news that came out a week ago that a candidate "malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal”. While the findings are still in preprint with The Lancet, the resulting buzz and phrases quoted included…
 
Playing out against the backdrop of a global pandemic (including recent massive surges in regions around the world) is the news that came out a week ago that a candidate "malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal”. While the findings are still in preprint with The Lancet, the resulting buzz and phrases quoted included…
 
Inside sales, field sales, product-led, channel sales, marketing, post-sales… a16z GTM is our clubhouse show for enterprise founders and builders about what it takes to go to market and the evolving strategies and lessons learned from enterprise companies past and present. Every other Thursday 4-5pm with David Ulevitch. For our upcoming schedule of…
 
a16z cofounders Marc Andreessen and Ben Horowitz answer questions on tech trends, company building, and more live on Clubhouse Mondays at 7pm PT. In this conversation: Which institution will last longer Harvard or the US? [00:58] How do you craft a good culture in a high pressure environment? [13:45] When will we have AGI? [31:15] Are network effec…
 
In this episode: Jim Messina - CEO, The Messina Group; formerly Obama's Deputy Chief of Staff; known as the "fixer" and "the most powerful person in Washington you've never heard of" Adrian Durbin - currently at Greenbrier; former Director of Policy Comms at Lyft Risa Heller - CEO of Risa Heller Communications; former Director of Comms for Senator …
 
On this episode of the a16z Bio Clubhouse Show, a16z general partners Vineeta Agarwala, Julie Yoo, and Jorge Conde talk to guests Sean Duffy, cofounder and CEO of Omada Health, Karan Singh, cofounder and COO of Ginger, and Chris Hogg, a serial entrepreneur in the digital health space. The conversation covers go-to-market strategies, financing and a…
 
In this episode: Jamie Byrne, Senior Director of Creator Partnerships, YouTube Shishir Mehrotra, former Director of Product Management, YouTube; former VP of Product, Engineering, UX, YouTube; current Founder & CEO, Coda Shiva Rajaraman, former Director, Product Management (etc.); current VP Shops and Business, Facebook Lauren Riihimimaki (aka Laur…
 
Today we are re-running an episode exploring a question that seems super straightforward, but that on closer examination reveals incredible complexity, and that is "how do we put the patient at the center of the healthcare system?” It almost seems counterintuitive, since aren’t patients always the center of healthcare? But healthcare is a strange i…
 
In this week’s episode of 16 Minutes, our show where we cover tech trends in the news — and also cover themes from company developer and innovation events! — we focus on the latest coming out of Apple’s event this week. The company announced a bunch of things, ranging from new device colors and form factors to podcast services, but in this episode …
 
a16z cofounders Marc Andreessen and Ben Horowitz answer questions on tech trends, company building, and more live on Clubhouse Mondays at 7pm PT. In this conversation: NFTs and tokenization — how will they impact the arts, media, music and investing strategies? The potential for DeFi Using shocking new rules to create culture Structuring options to…
 
a16z Infra is the Clubhouse Show where the a16z enterprise team and guests discuss the foundational technology and products that underpin all of tech. We dig deep into data, AI/ML, security, developer tools, compute, network, storage, hardware, and anything else found below the surface of modern stacks. Like what you hear? Tune in for our next show…
 
On this episode of the a16z Bio Clubhouse Show, a16z general partners Vineeta Agarwala, Julie Yoo, and Jorge Conde talk to guest Connie Chen, Chief Medical Officer at Lyra health. The conversation covers what makes digital health different from traditional healthcare delivery, how to build a sustainable business model while maintaining high standar…
 
In 1994, 29 bald eagles were found dead at DeGray Lake in Arkansas. This mass mortality event kicked off a search for the culprit which has last over 25 years. On this episode of the Bio Eats World Journal Club, host Lauren Richardson talks to Susan B. Wilde of the University of Georgia about her group's work finally identifying the eagle killer, a…
 
Anduril founders and team members Joe Chen, Matt Grimm, Palmer Luckey, Brian Schimpf, and Trae Stevens in conversation with Big Ideas show on Clubhouse co-host Katherine Boyle (along with Antonio Garcia-Martinez, Erik Torenberg, and Marc Andreessen).By Palmer Luckey, Katherine Boyle, Matt Grimm, Brian Schimpf, Trae Stevens, Joe Chen
 
We have two brief segments in today’s episode: News and analysis of the Johnson & Johnson COVID vaccine pause, and the widespread hack of Microsoft Exchange Servers across the country (and the dramatic and unusual steps the FBI took in response). Johnson & Johnson: Federal health officials last week revealed that six women who received the vaccine …
 
On this episode of Boss Talk: How do the best product marketers see and explain a trend? How much is the best marketing truth vs. spin? Does the marketing function create the strategy or execute on it? What are the core skills and competencies of a great product marketer — and how do you find, or train, product marketers? Should you create a catego…
 
This is a special episode of the a16z podcast — it's an audio history, told through the voices of the a16z crypto team, about what crypto is, how it really works, and why it matters. This "innovation overview" is meant as a resource, and it features hallway-style conversations with the a16z team as well as outside experts. In brief segments, we’ll …
 
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