EPISODE 119 - DNA FOCUS - ADH1C GENE

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This week we look at ADH1C. If you’ve ever heard that a glass of red wine per day is good for your heart, this is truer for some people than others based on their genetics.

Studies Referenced in the Episode:

https://www.ncbi.nlm.nih.gov/pubmed/9285651

http://www.nejm.org/doi/full/10.1056/NEJM199712113372401#t=abstract)

https://www.researchgate.net/publication/5805190_Alcohol_consumption_alcohol_dehydrogenase_and_risk_of_coronary_heart_disease_in_the_MONICAKORA-Augsburg_cohort_19941995-2002

https://www.ncbi.nlm.nih.gov/pubmed/16018848

https://www.ncbi.nlm.nih.gov/pubmed/16018848

ADH1C Genotype

Effect

AA

Fast metaboliser of alcohol – not associated with higher a lowering of cardiovascular disease risk in moderate drinkers; this effect is neutral, as opposed to negative.

AG/GG

Slow metaboliser of alcohol – associated with a reduction in cardiovascular disease risk with moderate amounts of alcohol.

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