EPISODE 124 - DNA FOCUS - PPARA

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In this week's edition of our blog, we look at PPARA, a gene that affects how well we can respond to different types of training, and as a result appears in our power-endurance algorithm. PPARA creates peroxisome proliferator-activated receptor alpha, a protein which activates other genes, as well as being a regulator of fatty acid oxidation during exercise. The gene is activated when our cells aren’t getting enough energy, such as when we fast, or when we take part in exercise that uses up our energy stores, such as endurance exercise.

PPARA Genotype

Training Effects

GG

This genotype is associated with improvements from endurance training; typically has higher amounts of slow twitch muscle fibres.

GC

Associated with improvements from both power and endurance training.

CC

Associated with enhanced improvements from power-based training. Typically have a greater proportion of fast-twitch muscle fibres.

Resources & Studies Mentioned

https://www.researchgate.net/publication/269508960_Relating_fitness_phenotypes_to_genotypes_in_Lithuanian_elite_athletes

https://www.researchgate.net/publication/230852500_The_association_of_ACE_ACTN3_and_PPARA_gene_variants_with_strength_phenotypes_in_middle_school-age_children

169 episodes