EPISODE 127 - DNA FOCUS - AGT

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This week, we turn our attention in this to AGT, a gene that appears in both our fitness and diet reports. This gene plays a role in how well we respond to power-based training, and so appears in our power-endurance profile, and also plays a role in blood pressure control, and hence appears in our salt sensitivity section. AGT is similar to ACE, a gene we looked at earlier in this series, in that it creates a protein that can cause our blood pressure to go up or down – the protein in this case being called angiotensinogen.

AGT Genotype

Training Response

Sodium Sensitivity

CC

Associated with an enhanced improvement to power and strength based training.

Associated with an increased risk of developing hypertension, particularly when salt intake is high. C allele carriers should limit their sodium intake.

CT

A moderate form of CC; smaller improvements expected as a response to strength and power training.

Associated with an increased risk of developing hypertension, particularly when salt intake is high. C allele carriers should limit their sodium intake.

TT

No enhanced improvements following strength and power training.

Not associated with an increased sensitivity to sodium with regards to hypertension.

Resources & Studies Mentioned

https://www.ncbi.nlm.nih.gov/pubmed/20029521

https://www.ncbi.nlm.nih.gov/pubmed/9403549

https://www.ncbi.nlm.nih.gov/pubmed/18689375

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