EPISODE 129 - DNA FOCUS - ADRB3

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By My DNA Coach. Discovered by Player FM and our community — copyright is owned by the publisher, not Player FM, and audio is streamed directly from their servers. Hit the Subscribe button to track updates in Player FM, or paste the feed URL into other podcast apps.

This week we are investigating ADRB3, a gene which appears in our fat sensitivity panel. This gene encodes for beta-3-adrenergic receptors, which are located mainly is fat tissue. They play a role in breaking down fat for use as energy, and a small change in this gene, known as a single nucleotide polymorphism (SNP), is thought to determine how well we can tolerate saturated fats.

ADRB3 Genotype

Findings

CC/CT

The C allele is associated with reduced fat cell breakdown, and is also associated with a higher BMI and increased energy intake, especially for fats. C allele carriers may also find it a bit harder to lose fat.

TT

Associated with the normal sensitivity to fat, and the normal amount of fat loss in a diet.

Resources & Studies Mentioned

http://www.nejm.org/doi/full/10.1056/NEJM199508103330604#t=article

https://www.ncbi.nlm.nih.gov/pubmed/22774474

https://www.ncbi.nlm.nih.gov/pubmed/18054709

169 episodes