EPISODE 132 - DNA FOCUS - TNF

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This episode explores TNF, which creates tumor necrosis factor. TNF is a pro-inflammatory cytokine - higher levels of TNF are associated with higher levels of inflammation, which can have an impact on various health risks, as well as our ability to recover from exercise. Higher levels of TNF following exercise are associated with higher levels of C-Reactive Protein (CRP); this drives inflammation, requiring longer recovery times between hard training sessions.

TNF Genotype

Effect on Recovery

Effect on Nutrition

GG

Associated with lower levels of inflammation after hard training sessions, leading to quicker recovery times.

The standard expression of TNF, associated with normal levels of cytokines.

GA

May experience increased levels of inflammation after hard exercise. A longer rest period between training sessions might be required.

This genotype is associated with a moderately increased level of inflammation. Consume slightly higher amounts of omega-3.

AA

May experience higher levels of inflammation after hard exercise, requiring longer recovery times between training sessions.

Associated with increased inflammation – aim for 3g of omega-3 per day.

Resources & Studies Mentioned

https://www.ncbi.nlm.nih.gov/pubmed/16581306)

https://www.ncbi.nlm.nih.gov/pubmed/26248682

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023559/

https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0063678/

https://www.ncbi.nlm.nih.gov/pubmed/16825676

https://www.ncbi.nlm.nih.gov/pubmed/12145022

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