EPISODE 138 - DNA FOCUS - FABP2

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By My DNA Coach. Discovered by Player FM and our community — copyright is owned by the publisher, not Player FM, and audio is streamed directly from their servers. Hit the Subscribe button to track updates in Player FM, or paste the feed URL into other podcast apps.

This week we turn our attention to FABP2, a gene that appears in both the carbohydrate and saturated fat parts of our reports. This gene creates a protein called Fatty Acid Binding Protein-2, which is found in our small intestines. FABP2 binds to the various different fatty acids, and allows them to be absorbed into the body.

The single nucleotide polymorphism (SNP) that we are interested in occurs when an alanine nucleotide is swapped for a threonine nucleotide; this substitution causes the protein to become more efficient. So efficient, in fact, that it doubles the speed at which we absorb these fats, leading to an increase of fat in the blood stream.

FABP2 Genotype

Findings

GG

This genotype is not associated with an increased sensitivity to saturated fats or refined carbohydrates.

GA

A single copy of the A allele is associated with a moderately increased sensitivity to saturated fats and refined carbohydrates.

AA

Two copies of the A allele of FABP2 means that this genotype is associated with a significantly increased sensitivity to both saturated fats and refined carbohydrates.

Resources & Studies Mentioned

http://www.atherosclerosis-journal.com/article/S0021-9150(09)01007-7/abstract

http://ajcn.nutrition.org/content/85/1/102.long)

169 episodes