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EPISODE 139 - DNA FOCUS - PPARGC1A
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This week to turn our attention to PPARGC1A, or as we call it at My DNA Coach, “the one with the long name”. This gene encodes for a protein called peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a), which causes some of the positive changes that occur in our body following exercise. One of the ways that exercise can lead to improvements is through something called mitochondrial biogenesis, which is the production of new mitochondria within the muscle itself.
The GG genotype is associated with a more positive response to endurance training, suggesting that it should comprise a greater part of a training programme.
The A allele is associated with a smaller response to endurance training, suggesting that power training might be more appropriate.
Resources & Studies Mentioned