EPISODE 139 - DNA FOCUS - PPARGC1A

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By My DNA Coach. Discovered by Player FM and our community — copyright is owned by the publisher, not Player FM, and audio is streamed directly from their servers. Hit the Subscribe button to track updates in Player FM, or paste the feed URL into other podcast apps.

This week to turn our attention to PPARGC1A, or as we call it at My DNA Coach, “the one with the long name”. This gene encodes for a protein called peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a), which causes some of the positive changes that occur in our body following exercise. One of the ways that exercise can lead to improvements is through something called mitochondrial biogenesis, which is the production of new mitochondria within the muscle itself.

PPARGC1A Genotype

Effect

GG

The GG genotype is associated with a more positive response to endurance training, suggesting that it should comprise a greater part of a training programme.

AG/AA

The A allele is associated with a smaller response to endurance training, suggesting that power training might be more appropriate.

Resources & Studies Mentioned

https://www.ncbi.nlm.nih.gov/pubmed/15705733

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